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Title:The Development of Novel Non -Steroidal Subtype Selective Ligands for the Estrogen Receptor
Author(s):Mortensen, Deborah Sue
Doctoral Committee Chair(s):Katzenellenbogen, John A.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Pharmaceutical
Abstract:A series of furan analogs were prepared bearing basic side-chains in the hope to impart anti-estrogenic activity to this class of ligands. The basic side-chain furan analogs were also ER-alpha binding selective ligands (2--47 fold selectivity) and transcriptional assays have shown one particular member of this series (Chapter 5, 17b) to be an ER-alpha selective antagonist (∼10 fold selectivity).
Issue Date:2000
Type:Text
Language:English
Description:154 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2000.
URI:http://hdl.handle.net/2142/84490
Other Identifier(s):(MiAaPQ)AAI9990091
Date Available in IDEALS:2015-09-25
Date Deposited:2000


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