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Title:Lateral Membrane Domains Organize and Regulate Components of Signal Transduction Pathways
Author(s):Wanaski, Stephen Philip
Doctoral Committee Chair(s):Glaser, Michael
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:Components of the mitogen activated protein kinase (MAPK) signaling cascade also localized into domains in vesicles containing acidic lipids. The formation of lateral membrane domains induced by Ki-Ras 4B and the Raf-cysteine rich domain (Raf-CRD) was inhibited by the anti-tumor agent farnesylthiosalicylic acid (FTS). The inhibition of Ras membrane domains by farnesylthiosalisylic acid was proposed to inhibit Ras function and the results provided a model of how the membrane organizes and regulates the MAP kinase signaling cascade.
Issue Date:2001
Type:Text
Language:English
Description:194 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.
URI:http://hdl.handle.net/2142/84774
Other Identifier(s):(MiAaPQ)AAI3017244
Date Available in IDEALS:2015-09-25
Date Deposited:2001


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