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Title:Engineering and Characterization of High-Affinity T Cell Receptors
Author(s):Holler, Phillip David
Doctoral Committee Chair(s):Kranz, David M.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Health Sciences, Immunology
Abstract:In Chapter 6, the role of TCR affinity in T cell activation was studied using CD8-negative T cells, as well as T cells expressing the co-receptor CD8. The peptide sensitivity of T cells that expressed the highest-affinity TCRs reached a plateau, suggesting the existence of an affinity maximum for T cell activation. Furthermore, CD8 requirements were directly related to the affinity of the TCR.
Issue Date:2002
Type:Text
Language:English
Description:156 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/84786
Other Identifier(s):(MiAaPQ)AAI3070327
Date Available in IDEALS:2015-09-25
Date Deposited:2002


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