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Title:Chemotactic Sensory Transduction in Bacillus Subtilis: A New Enzyme and a New Pathway
Author(s):Kristich, Christopher James
Doctoral Committee Chair(s):Geroge W. Ordal
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Microbiology
Abstract:Chemotaxis towards substrates of the phosphoenolpyruvate-dependent-phosphotransferase system (PTS) in E. coli is accomplished using a chemoreceptor-independent signaling circuit in which phosphoryl flux through the PTS is monitored and used directly to modulate the activity of the chemotactic kinase. In contrast, chemotaxis towards PTS carbohydrates by B. subtilis requires the transmembrane chemoreceptor McpC; therefore, B. subtilis must employ a different sensory circuit to mediate such chemotaxis. The results in this study indicate that the sensory circuit mediating chemotaxis towards PTS carbohydrates utilizes the cytoplasmic methyl-accepting subdomain of McpC as a sensor for PTS stimuli. This receptor subdomain has not been reported to function as a sensor of chemical stimuli for any known chemoreceptor.
Issue Date:2002
Type:Text
Language:English
Description:110 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/84787
Other Identifier(s):(MiAaPQ)AAI3070359
Date Available in IDEALS:2015-09-25
Date Deposited:2002


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