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Title:Characterization of Antigen Recognition by a T Lymphocyte Clone
Author(s):Lee, Peter, Uang-Yin
Doctoral Committee Chair(s):Kranz, David M.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Health Sciences, Immunology
Abstract:Chapter Four addresses the physiological T cell responses that can be elicited by peptide/MHC recognition. We demonstrated that the endogenously derived peptide, dEV8, functioned as both an agonist and an antagonist of T cells derived from 2C TCR transgenic mice. Although the exact mechanism underlying the opposing effects of the same pepMHC complex remains to be determined, differences in accessory molecules or coreceptors on the T cell surface may have a significant impact on T cell signaling and function.
Issue Date:2002
Type:Text
Language:English
Description:122 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/84802
Other Identifier(s):(MiAaPQ)AAI3102037
Date Available in IDEALS:2015-09-25
Date Deposited:2002


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