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Title:Regulation and Functionality of Stress-Induced Cytochrome P450 Monooxygenases: A Functional Genomics Approach
Author(s):Civjan, Natanya R.
Doctoral Committee Chair(s):Sligar, Stephen G.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:Whereas Arabidopsis P450s are typically membrane-associated, the hydrophobic nature of membrane-binding regions oftentimes creates difficulties in the solubilization, isolation and study of these proteins using traditional biochemical techniques. Paralleling the study of individual P450s was the development of a biotechnique to transfer membrane proteins directly from partially fractionated cellular membranes into soluble nanostructures that contain a native-like membrane environment. The resulting system is conducible to many of the biochemical methodologies previously restricted to soluble proteins and adds another tool to aid in the characterizations of this important class of enzymes.
Issue Date:2005
Type:Text
Language:English
Description:118 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.
URI:http://hdl.handle.net/2142/84815
Other Identifier(s):(MiAaPQ)AAI3198956
Date Available in IDEALS:2015-09-25
Date Deposited:2005


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