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Title:Characterization of Leucyl -Trna Synthetase From Escherichia Coli and Saccharomyces Cerevisiae in Aminoacylation, Amino Acid Editing, and Protein-Dependent RNA Splicing
Author(s):Hsu, Jennifer Ling
Doctoral Committee Chair(s):Susan Martinis
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:Using extensive deletion and site-directed mutagenesis, we characterized the C-terminal domain of LeuRSs from different origins to understand its role. The results demonstrated that the native environment of the enzyme influenced the functional role of the unique C-terminal domain of both LeuRSs. These combined biochemical investigations suggest that the yeast mitochondrial LeuRS C-terminal domain has uniquely adapted to accommodate aminoacylation, amino acid editing, and RNA-protein interactions.
Issue Date:2006
Type:Text
Language:English
Description:131 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.
URI:http://hdl.handle.net/2142/84835
Other Identifier(s):(MiAaPQ)AAI3250259
Date Available in IDEALS:2015-09-25
Date Deposited:2006


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