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Title:Characterization of Leucyl -Trna Synthetase From Saccharomyces Cerevisiae and Escherichia Coli in Aminoacylation, Amino Acid Editing and Enzyme Inhibition
Author(s):Nawaz, Mirhussain
Doctoral Committee Chair(s):Martinis, Susan A.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:Because they are essential to protein synthesis, aaRSs offer a promising target for the development of novel drugs. Leucyl-adenylate analogs were tested for inhibition activity against LeuRS from different sources. These analogs efficiently inhibited the E. coli and Saccharomyces cerevisiae mitochondrial LeuRS enzymes with low nanomolar K I's, but had no inhibitory effects on the eukaryotic S. cerevisiae cytoplasmic LeuRS enzyme.
Issue Date:2007
Type:Text
Language:English
Description:141 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
URI:http://hdl.handle.net/2142/84841
Other Identifier(s):(MiAaPQ)AAI3269990
Date Available in IDEALS:2015-09-25
Date Deposited:2007


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