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Title:Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
Author(s):Thu, Thant Si
Doctoral Committee Chair(s):Glaser, Michael
Department / Program:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Molecular
Abstract:In addition to steroid hormones, signaling by platelet-derived growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the sciatic nerve of the null mice. Furthermore, cocultures established with DRG neurons and Schwann cells from the null mice showed decreased expression of myelin basic protein (MBP) transcripts. PDGF-A null Schwann cells differentiating into the myelinating phenotype without neurons expressed lower levels of MBP and 3beta-hydroxysteroid dehydrogenase mRNAs and produced less progesterone and its metabolites. Treatment of the differentiating Schwann cells with PDGF-A increased the expression of MBP and the production of progesterone and its metabolites. Together, these results shed light on the importance of steroid hormones, growth factors, and their interaction in the process of myelin synthesis in the peripheral nervous system.
Issue Date:2007
Description:159 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
Other Identifier(s):(MiAaPQ)AAI3301235
Date Available in IDEALS:2015-09-25
Date Deposited:2007

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