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Title:Mechanistic Investigations of Dehydration of Lacticin 481 Synthetase and Exploring Its Biochemical Applications
Author(s):You, Young-Ok
Doctoral Committee Chair(s):van der Donk, Wilfred A.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:Developing a selective labeling method for peptides/proteins is of great interest in numerous research areas. In order to explore this idea, a strategy was developed through which an N-terminal ketone was introduced by using the LctA-LctM modification system. Finally, analysis of phosphorylated LctA intermediates in collaboration with Professor Kelleher's laboratory revealed dehydration of LctM takes place with directionality, moving from the N-terminus to the C-terminus of the substrates.
Issue Date:2008
Type:Text
Language:English
Description:126 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
URI:http://hdl.handle.net/2142/84858
Other Identifier(s):(MiAaPQ)AAI3337975
Date Available in IDEALS:2015-09-25
Date Deposited:2008


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