Files in this item

FilesDescriptionFormat

application/pdf

application/pdf3362752.pdf (5MB)Restricted to U of Illinois
(no description provided)PDF

Description

Title:The Role of T Cell Receptor: Peptide MHC Affinity in T Cell Activation
Author(s):Chervin, Adam S.
Doctoral Committee Chair(s):Kranz, David M.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:Engineering of TCRs requires stabilization of the receptor prior to engineering for higher affinity. Chapter 4 details the engineering of a high affinity TCR in its native state, without the need for stabilization, using a T cell display system. T cells bearing the newly isolated TCR bound pepMHC and were activated in the absence of co-receptor. This result demonstrates the feasibility of engineering full-length TCRs on the surface of T cells using a retroviral vector.
Issue Date:2009
Type:Text
Language:English
Description:115 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
URI:http://hdl.handle.net/2142/84862
Other Identifier(s):(MiAaPQ)AAI3362752
Date Available in IDEALS:2015-09-25
Date Deposited:2009


This item appears in the following Collection(s)

Item Statistics