Files in this item

FilesDescriptionFormat

application/pdf

application/pdf3455890.pdf (12MB)Restricted to U of Illinois
(no description provided)PDF

Description

Title:In Search of Catalytic Proficiency: The Importance of Enzyme Conformational Change to Orotidine 5'-Monophosphate Decarboxylase Catalysis
Author(s):Wood, Bryant McKay
Doctoral Committee Chair(s):Gerlt, John A.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Physical
Abstract:By applying the tools of enzymology learned in the Gerlt Laboratory and working successfully with numerous collaborators, I have furthered our understanding of the mechanism of one of Nature's best catalysts, OMPDC. Increasingly in enzymology, the role of conformational change in enzyme catalysis has been recognized as an important one. This research has shed light on the conformational changes that take place when substrate binds OMPDC and how the two events are coordinated.
Issue Date:2010
Type:Text
Language:English
Description:294 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2010.
URI:http://hdl.handle.net/2142/84872
Other Identifier(s):(MiAaPQ)AAI3455890
Date Available in IDEALS:2015-09-25
Date Deposited:2010


This item appears in the following Collection(s)

Item Statistics