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Title:Oxidation of Alkenes by Caldariomyces Fumago Chloroperoxidase
Author(s):Dexter, Annette Faith
Doctoral Committee Chair(s):Hager, Lowell P.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:To elucidate factors involved in the control of CPO heme N-alkylation by terminal alkenes, the epoxidation of a series of monosubstituted and 1,1-disubstituted terminal alkenes by CPO was investigated. Terminal alkenes containing a 2-methyl substituent did not inactivate CPO even when the corresponding monosubstituted alkene inactivated the enzyme. The inverse correlation between the epoxidation enantioselectivity and the tendency to heme N-alkylation suggested that CPO inactivation by terminal alkenes is controlled by steric properties of the alkene and the enzyme active site. (Abstract shortened by UMI.).
Issue Date:1997
Type:Text
Language:English
Description:265 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997.
URI:http://hdl.handle.net/2142/84876
Other Identifier(s):(MiAaPQ)AAI9717270
Date Available in IDEALS:2015-09-25
Date Deposited:1997


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