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Title:Recombinant Hemoglobin Variants: Structure-Function Analysis and Oxygen Therapeutic Design
Author(s):Sanders, Kevin Eugene
Doctoral Committee Chair(s):Sligar, Stephen G.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Molecular
Abstract:In a rat model each protein exhibited an increased vascular lifetime and no renal excretion. Furthermore, a dose dependent increase in vascular lifetime was observed suggesting that the protein clearance mechanism is saturatable. These circularly permuted variants represent the first recombinantly designed polymerized hemoglobin. The clear structural and functional similarity of these variants to native hemoglobin and improved vascular stability suggests that they have potential for use as an oxygen carrying therapeutic.
Issue Date:1998
Type:Text
Language:English
Description:129 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998.
URI:http://hdl.handle.net/2142/84898
Other Identifier(s):(MiAaPQ)AAI9912367
Date Available in IDEALS:2015-09-25
Date Deposited:1998


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