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Title:Intestinal Development and Gene Expression of Piglets Suckling Sows Transgenic for Human Insulin-Like Growth Factor-I
Author(s):Hartke, Jessica L.
Doctoral Committee Chair(s):Donovan, Sharon M.
Department / Program:Nutritional Sciences
Discipline:Nutritional Sciences
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Health Sciences, Nutrition
Abstract:We have shown that piglets suckling IGF exhibit structural and functional changes similar to those observed in piglets receiving formula supplemented with IGF-I. The location and timing of the response to IGF-I differs from previous studies. Insulin like growth factor-I appeared to act via the type I IGF receptor at d 21 in the ileum of piglets suckling IGF. Microarray analysis elucidated differentially expressed genes involved in proliferation, as well as genes involved in immune function and metabolism, suggesting new avenues for IGF-I research.
Issue Date:2006
Description:182 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.
Other Identifier(s):(MiAaPQ)AAI3242863
Date Available in IDEALS:2015-09-25
Date Deposited:2006

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