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Title:Combination of Dietary Tomato and Broccoli Powders Are Effective Growth Inhibitors of Dunning R3327-H Prostate Adenocarcinomas
Author(s):Adams, Kirstie Anne-Merrea
Doctoral Committee Chair(s):Erdman, John W.
Department / Program:Nutritional Sciences
Discipline:Nutritional Sciences
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Health Sciences, Oncology
Abstract:Tumor growth suppression was associated with reduced proliferation and increased apoptosis, as quantified by Proliferating Cell Nuclear Antigen (PCNA) immunohistochemistry and the ApoptagRTM assay, respectively. Utilizing real time polymerase chain reactions (RT-PCR) and the SYBR Green assay, mRNA was quantified in the liver, prostate, and tumors. Finasteride significantly decreased expression of 5-alpha-reductase-II, Bcl-2, and IL-6 in tumors. IL-6 was reduced in high lycopene and broccoli, P=0.05, and TNF-alpha was lower with low lycopene, P=0.05. Overall, the combination of tomato and broccoli powders was more effective at slowing tumor growth than either tomato powder or broccoli powder alone.
Issue Date:2007
Type:Text
Language:English
Description:140 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
URI:http://hdl.handle.net/2142/84950
Other Identifier(s):(MiAaPQ)AAI3269826
Date Available in IDEALS:2015-09-25
Date Deposited:2007


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