Files in this item



application/pdf3362775.pdf (1MB)Restricted to U of Illinois
(no description provided)PDF


Title:The Effect of Dietary Genistein on Breast Cancer Treatment and Metastasis
Author(s):Du, Mengyuan
Doctoral Committee Chair(s):Cooke, Paul S.; Helferich, William G.
Department / Program:Nutritional Sciences
Discipline:Nutritional Sciences
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Health Sciences, Nutrition
Abstract:In the first study, we demonstrated that low dose dietary genistein negated the inhibitory effect of tamoxifen on mammary tumor growth. Although high dose genistein did not show the same effect, high tumor prevalence was observed. In the second study, dietary genistein was shown to promote breast cancer metastasis to lungs in athymic mice. The results from these studies suggest that the consumption of dietary supplements containing genistein may not be safe to breast cancer survivors. In our third study, we evaluated three metastasis models using different injection sites. We have successfully developed animal models that can produce a proper level of distant metastasis. These preclinical animal models will allow us to conduct further research to investigate the impact of soy isoflavones on breast cancer metastasis in the future.
Issue Date:2009
Description:103 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
Other Identifier(s):(MiAaPQ)AAI3362775
Date Available in IDEALS:2015-09-25
Date Deposited:2009

This item appears in the following Collection(s)

Item Statistics