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Title:The Mechanism of Chemoprotection by 1-Cyano-2-Hydroxy-3-Butene, a Natural Component of Cruciferous Vegetables
Author(s):Staack, Richard Frank
Doctoral Committee Chair(s):Jeffery, Elizabeth H.
Department / Program:Nutritional Sciences
Discipline:Nutritional Sciences
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Health Sciences, Oncology
Abstract:In a final study, CHB was found to mediate a monofunctional DNA-directed increase in GST subunit Ya$\sb2,$ Yc$\sb2$ and QR mRNA levels, without a concomitant increase in mRNA levels of CYP 1A. This suggests that, in the previous study, the protection afforded against aflatoxin-induced carcinogenesis was through a monofunctional increase in phase II enzymes, particularly, the GST subunit Yc$\sb2.$ (Abstract shortened by UMI.).
Issue Date:1997
Type:Text
Language:English
Description:170 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997.
URI:http://hdl.handle.net/2142/84976
Other Identifier(s):(MiAaPQ)AAI9812780
Date Available in IDEALS:2015-09-25
Date Deposited:1997


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