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Title:Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells
Author(s):Baldeon, Manuel Eduardo
Doctoral Committee Chair(s):Gaskins, H. Rex
Department / Program:Nutritional Sciences
Discipline:Nutritional Sciences
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Animal Physiology
Abstract:Conclusions. Interferon-$\gamma,$ but not IFN-$\alpha,$ has a direct pathogenic role on the pancreatic $\beta$-cell. Early expression of IFN-$\alpha$ by the $\beta$-cell may contribute to insulitis whereas IFN-$\gamma,$ a product of islet infiltrating leukocytes, may mediate characteristic decreases in glucose sensitivity and increased cell surface expression of MHC class $\rm I\sb{A}$ in the prediabetic $\beta$-cell. Enhanced expression of the MHC class $\rm I\sb{A}$ antigen processing and presentation pathway and diminished insulin production appear to be distinct pathologic alterations in $\beta$-cells exposed to the insulitic cytokine IFN-$\gamma.$.
Issue Date:1998
Type:Text
Language:English
Description:128 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998.
URI:http://hdl.handle.net/2142/84978
Other Identifier(s):(MiAaPQ)AAI9904386
Date Available in IDEALS:2015-09-25
Date Deposited:1998


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