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Title:Intestinal Uptake of Carotenoids: Implications for Carotenoid Bioavailability
Author(s):Boileau, Amy Christine
Doctoral Committee Chair(s):John W. Erdman, Jr.
Department / Program:Nutritional Sciences
Discipline:Nutritional Sciences
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Health Sciences, Public Health
Abstract:Lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. The observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans lycopene, has led to the hypothesis that cis-isomers of lycopene are more bioavailable. When bile acid micelles were prepared in vitro from crystalline lycopene, cis-isomers of lycopene were significantly enriched in the optically-clear micelle preparation. Mesenteric lymph duct cannulated ferrets were used to study the in vivo absorption of lycopene. Following an oral dose, lymph was collected for 2 hours. The lymph secretions contained a significantly greater proportion of cis-lycopene than any other fraction (P < 0.01). These studies demonstrate that in ferrets, cis-isomers of lycopene are more bioavailable than the all-trans isomer.
Issue Date:1999
Description:132 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.
Other Identifier(s):(MiAaPQ)AAI9952968
Date Available in IDEALS:2015-09-25
Date Deposited:1999

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