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Title:Testosterone, Lycopene Isomers, and Prostate Cancer
Author(s):Boileau, Thomas William-Maxwell
Doctoral Committee Chair(s):John W. Erdman, Jr.
Department / Program:Nutritional Sciences
Discipline:Nutritional Sciences
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Health Sciences, Oncology
Abstract:The objective of the final study was to determine the influence of purified lycopene, tomato powder, and 20% diet restriction on N-methyl-N-nitrosourea (NMU)-testosterone-induced prostate cancer in rats. Survival was analyzed to include only rats that died with adenocarcinomas of the accessory sex glands. Only tomato powder-fed (RR = 0.570; P = 0.009) rats experienced significantly increased survival as compared to placebo beadlet-fed control rats. No significant influences of lycopene beadlet feeding or diet restriction as well as no interactions were noted for accessory sex gland-specific survival. We conclude that tomato powder may contain compounds, in addition to lycopene, which favorably modulate prostate carcinogenesis.
Issue Date:2001
Description:152 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.
Other Identifier(s):(MiAaPQ)AAI9996618
Date Available in IDEALS:2015-09-25
Date Deposited:2001

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