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Title:Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Fentanyl in Dogs
Author(s):Grimm, Kurt Allan
Doctoral Committee Chair(s):David R. Gross
Department / Program:Biology
Discipline:Biology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Animal Physiology
Abstract:Results of the bioequivalence analysis indicated the model was not equivalent. The model was examined using time averaged inputs of tissue blood flows and using stepped changes in tissue blood flow representing measured changes in individual experimental subjects. Analysis of partial areas under the curve suggested the model was better at predicting the elimination than the distribution of fentanyl, although the partial areas under the curve were still not equivalent.
Issue Date:2002
Type:Text
Language:English
Description:136 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/85344
Other Identifier(s):(MiAaPQ)AAI3070001
Date Available in IDEALS:2015-09-25
Date Deposited:2002


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