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Title:Coregulatory Transcription Factors and Spermatogenesis
Author(s):Morrow, Carla K.
Doctoral Committee Chair(s):Hess, Rex A.
Department / Program:Biology
Discipline:Biology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Molecular
Abstract:The BTB was hypothesized to be deficient in Etv5 -/- mice, and that this was mediated by Claudin 5 (CLD5). In both Etv5-/- and W/Wnu mice, the BTB was leaky. Examination of CLD5 expression among mice of various ages and phenotypes revealed the following: both ETV5 and germ cells were necessary for seminiferous epithelial CLD5 expression; CLD5 expression was ETV5 independent in vascular endothelium; and CLD5 was expressed in both Sertoli cells and spermatogonia. Data presented here support the conclusion that Sertoli cell CLD5 has a role in BTB function, but also a non-tight junction role in spermatogonia.
Issue Date:2008
Type:Text
Language:English
Description:213 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
URI:http://hdl.handle.net/2142/85379
Other Identifier(s):(MiAaPQ)AAI3337879
Date Available in IDEALS:2015-09-25
Date Deposited:2008


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