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Title:A Survey of Beta-Sheet Folding: WW Domains With Zinc Fingers and Membrane Peptides
Author(s):Nguyen, Houbi Tung Thanh
Doctoral Committee Chair(s):Martin Gruebele
Department / Program:Biophysics and Computational Biology
Discipline:Biophysics and Computational Biology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biophysics, General
Abstract:This work describes the present state of folding research involving small, fast-folding protein systems. By perturbing a WW domain sequence with side-chain mutations, truncations, amide-to-ester exchanges, and loop rearrangements we find that loop structures can dictate the folding dynamics of this model beta-sheet protein. We then report on a synthetic zinc-finger peptide used to bridge the gap between experimental and theoretical protein folding research. To complete our work we summarize ongoing research on the membrane interactions of a small alpha-helical peptide.
Issue Date:2004
Description:320 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.
Other Identifier(s):(MiAaPQ)AAI3160934
Date Available in IDEALS:2015-09-25
Date Deposited:2004

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