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Title:Structural and Biochemical Studies of Nisin *Biosynthesis and Autoimmunity
Author(s):Yu, John-Paul Jaewoon
Doctoral Committee Chair(s):Nair, Satish K.
Department / Program:Biophysics and Computational Biology
Discipline:Biophysics and Computational Biology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biophysics, General
Abstract:The lantibiotic nisin is a 34-residue bacteriocin produced by the Gram-positive bacteria Lactococcus lactis spp. It is first ribosomally synthesized as an inactive precursor which is then post-translationally modified into its mature biologically active form. Described herein is a two-part study investigating (1) the structural basis of how the characteristic nisin lanthionine rings are installed by the enzyme NisC and (2) how Lactococcus lactis spp., despite producing an effective bacteriocin like nisin, is resistant to the toxic effects of nisin. The results described here together provide the first structural insights into the biosynthesis of nisin as well as insights into how L. lactis demonstrates autoimmunity to the lantibiotic nisin.
Issue Date:2006
Type:Text
Language:English
Description:128 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.
URI:http://hdl.handle.net/2142/85455
Other Identifier(s):(MiAaPQ)AAI3223758
Date Available in IDEALS:2015-09-25
Date Deposited:2006


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