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Title:Simulation and Visualization of Dynamics in RNA·protein Complexes in Translation
Author(s):Eargle, John
Doctoral Committee Chair(s):Zaida Luthey-Schulten
Department / Program:Biophysics and Computational Biology
Discipline:Biophysics and Computational Biology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Chemistry, Biochemistry
Abstract:Finally, ongoing work is presented on the role of ribosomal signatures in the first steps of ribosomal assembly. Ribosomal signatures are features that are completely conserved within one domain of life but absent from the other domains. Correlations between rRNA signatures and signatures in the ribosomal proteins (r-proteins) show that the rRNA signatures coevolved with both domain specific r-proteins and inserts in universal r-proteins. The largest bacterial structural rRNA signature with such a coevolutionary protein partner is found in the five-way junction of the 16S rRNA 5' domain, which is held together by the universal r-protein S4. We characterize the dynamics and flexibility of the free S4 structural signature and rRNA signature helix 16 (h16) as well as the S4·h16 complex. Investigation into the folding and binding of these components will be carried out using Go-like potentials to bias the complex structure towards its native state.
Issue Date:2010
Description:187 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2010.
Other Identifier(s):(MiAaPQ)AAI3430962
Date Available in IDEALS:2015-09-25
Date Deposited:2010

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