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Title:Isolation and Characterization of a Novel Gene, xMADML, Involved in Xenopus Laevis Eye Development Using Cornea -Lens Regeneration
Author(s):Elkins, Matthew Brian
Doctoral Committee Chair(s):Jonathan Joseph Henry
Department / Program:Cell and Developmental Biology
Discipline:Cell and Developmental Biology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Cell
Abstract:One clone was isolated from the cDNA library on the basis of its embryonic expression pattern and its sequence similarity to human NRBP and mouse MADM genes. This gene, xMADML, was characterized through molecular analysis, which showed both similarity and important differences to MADM, and protein knock-down, which showed that xMADML is necessary in both the developing retina and lens. Analysis of the expression patterns of known genes in the xMADML-knockdown background showed that expression of some genes, particularly Pax6, were altered, whereas the expression patterns of other genes were not. This suggests that xMADML is involved in the signaling cascades necessary to control retina and lens development. Further understanding of the genetic controls of eye development will allow for increased understanding of the general process of development.
Issue Date:2006
Type:Text
Language:English
Description:152 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.
URI:http://hdl.handle.net/2142/86308
Other Identifier(s):(MiAaPQ)AAI3250236
Date Available in IDEALS:2015-09-28
Date Deposited:2006


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