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Title:Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
Author(s):Miao, Ji
Doctoral Committee Chair(s):Kemper, Jongsook K.
Department / Program:Cell and Developmental Biology
Discipline:Cell and Developmental Biology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Cell
Abstract:These combined studies should greatly advance our understanding of how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 signaling pathways, and SHP ligand can dramatically increase SHP protein stability and abnormal regulation of SHP protein stability is associated with pathological disease conditions, indicating that regulation of SHP protein stability is a critical mechanism to regulate SHP activity. Since SHP plays a critical role in diverse cellular pathways, including bile acid/cholesterol and lipid/glucose homeostasis, and cell proliferation, this study to define how SHP activity is modulated by bile acids, FGF15/19 and its ligands, may reveal novel molecular targets for treating disorders in which SHP plays a key regulatory role. (Abstract shortened by UMI.).
Issue Date:2008
Description:206 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
Other Identifier(s):(MiAaPQ)AAI3347449
Date Available in IDEALS:2015-09-28
Date Deposited:2008

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