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Title:Effects of Exercise on Immune Function in Young, Adult, and Aged Mice: Increased Survival and a Decrease in Inflammation
Author(s):Lowder, Thomas W.
Doctoral Committee Chair(s):Jeff Woods
Department / Program:Kinesiology and Community Health
Discipline:Kinesiology and Community Health
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Physiology
Abstract:We have previously shown that moderate exercise for 4 days during a mounting immune response significantly increases survival during influenza virus (A/PR/8/34) infection in mice. We hypothesized that this brief duration of exercise resulted in a decreased level of lung histopathology while altering the immune response from a Th1 (inflammatory) to a Th2 (Anti-inflammatory) response. Adult male Balb/cByJ mice (5-6mo) were inflected with 50uL of A/PR/8/34 influenza virus (40HAU) intranasally under light anesthesia (Isoflurane) and randomized to either an exercise (EX) or sedentary (SED) group. EX mice performed 20-3min of moderate exercise (8-12m/min) on a motorized treadmill 4hr post-infection and then exercised similarly for 4 consecutive days. SED mice were exposed to similar environmental conditions but did not exercise. Mice from both EX and SED groups were sacrificed 1, 3, or 5 days post-infection lungs, mediastinal lymph nodes and spleens were harvested. We found a profound reduction in IFN-gamma in lungs of EX mice when compared to SED mice 3 and 5 days post-infection. There was also a reduction in viral gene mRNA expression, although not at the level of statistical significance (p=0.241). While there were no statistically significant differences in percentage or absolute number of CED8+ cells in the lungs of infected mice, EX mice had significantly fewer cells compared with SED mice 5 days post-infection. Interestingly, we found no observable difference in lung histopathology between groups. These data suggest that moderate exercise shifts the immune response from a Th1 to a Th2 profile in mice infected with influenza virus. This exercise-induced shift in immune response may be responsible for improved survival after influenza virus infection.
Issue Date:2006
Description:234 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.
Other Identifier(s):(MiAaPQ)AAI3250283
Date Available in IDEALS:2015-09-28
Date Deposited:2006

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