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Title:Regulation of Cell Migration by Integrin -Mediated Adhesion
Author(s):Cox, Elisabeth Abbot
Doctoral Committee Chair(s):Anna Huttenlocher
Department / Program:Microbiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Cell
Abstract:The second project focused on identifying new molecules involved in regulating integrin-mediated adhesion during cell migration. The technique of mammalian cDNA expression cloning was used to identify regulators of cell-substratum adhesion. Through this approach, a cDNA with homology to RACK1, a receptor for activated protein kinase C, was identified. Interestingly, this cDNA was found to be a truncated form of RACK1 that has one of the putative PKC binding sites, but lacks C-terminal sequences required to bind integrin beta cytoplasmic tails, and the tyrosine kinase, Src. Characterization of this molecule has demonstrated that RACK1, through its interaction with Src, plays an important role in regulating cell adhesion, protrusion, and directional cell migration.
Issue Date:2001
Description:124 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.
Other Identifier(s):(MiAaPQ)AAI3030423
Date Available in IDEALS:2015-09-28
Date Deposited:2001

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