Files in this item

FilesDescriptionFormat

application/pdf

application/pdf3044138.pdf (4MB)Restricted to U of Illinois
(no description provided)PDF

Description

Title:Analysis of Growth Cone Signaling During Axon Development in Drosophila Melanogaster
Author(s):Kim, Michael Dong
Doctoral Committee Chair(s):Chiba, Akira
Department / Program:Microbiology
Discipline:Microbiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Neuroscience
Abstract:In addition, I demonstrated that growth cones expressing constitutively active Cdc42 that displayed guidance defects exhibited little change in their filopodial activity when compared to wild type, whereas others without guidance defects exhibited a significant increase. Moreover, the Y40C effector-loop mutation exerted little influence over filopodial activity caused by Cdc42 activation despite its ability to suppress the guidance defects of the growth cones. Collectively, these data provide evidence that Cdc42 controls filopodial activity in axonal growth cones independently of its effects on their guidance. Furthermore, my studies begin to suggest that actin reorganization alone cannot mediate proper axon outgrowth or guidance.
Issue Date:2002
Type:Text
Language:English
Description:77 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/86638
Other Identifier(s):(MiAaPQ)AAI3044138
Date Available in IDEALS:2015-09-28
Date Deposited:2002


This item appears in the following Collection(s)

Item Statistics