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Title:Identification, Characterization and Mechanism of the Estrogen Regulation of the Gene Encoding the Sodium /Hydrogen Exchanger -Regulatory Factor (nhe-Rf)
Author(s):Ediger, Tracy Rene
Doctoral Committee Chair(s):Katzenellenbogen, Benita S.
Department / Program:Microbiology
Discipline:Microbiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Animal Physiology
Abstract:Finally, studies were designed to help define the physiological role of estrogen-induction of the NHE-RF gene using two model systems. Immunocytochemistry was used to visualize NHE-RF in MCF-7 cells. Secondly, we created adenovirus that express the wild type or anti-sense NHE-RF RNA. By infecting cells with the adenovirus we may overexpress or functionally "knock out" the NHE-RF protein and monitor the resulting effects on cell signaling, fluid exchange and cell cytoarchitecture.
Issue Date:2002
Type:Text
Language:English
Description:97 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/86642
Other Identifier(s):(MiAaPQ)AAI3070296
Date Available in IDEALS:2015-09-28
Date Deposited:2002


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