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Title:Cloning, Phenotypic, and Experimental Analysis of Pat-4: The Caenorhabditis Elegans Homologue of Integrin -Linked Kinase
Author(s):Mackinnon, Alexander Craig, Jr
Doctoral Committee Chair(s):Benjamin D. Williams
Department / Program:Microbiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Cell
Abstract:The third chapter describes experimental analysis of pat-4 during the morphogenesis of the excretory canal cell. By completely removing pat-4 expression from the excretory cell, I demonstrate that pat-4 is essential for the active outgrowth and complete extension of the excretory canal processes during embryogenesis and early larval development. Interestingly, "kinase-dead" and PH domain-disrupted forms of PAT-4/ILK support initial canal outgrowth. However, these canals frequently fail to fully extend during active canal outgrowth resulting in shortened, misshaped mature canals. These results identify a new developmental function for PAT-4/ILK in C. elegans and directly establish a role for ILK during the dynamic process of cellular morphogenesis in vivo .
Issue Date:2004
Description:126 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.
Other Identifier(s):(MiAaPQ)AAI3153370
Date Available in IDEALS:2015-09-28
Date Deposited:2004

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