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Title:Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation
Author(s):Hinthong, Olivia
Doctoral Committee Chair(s):Joanna Shisler
Department / Program:Microbiology
Discipline:Microbiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Virology
Abstract:This dissertation elaborates on M2's molecular functioning as a viral immunomodulator to inhibit both the ERK1/2 and NF-kappaB pathways, which is reliant on its glycosylation status and proper cellular trafficking within the infected cell. As M2 has no homology to any known viral or cellular protein, this suggests a novel immunoregulatory function. Data contained within this dissertation provides insight into the molecular mechanism of an ER-localized protein, and its impact on cytoplasmic signaling pathways within the context of an anti-viral immune response.
Issue Date:2010
Type:Text
Language:English
Description:187 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2010.
URI:http://hdl.handle.net/2142/86716
Other Identifier(s):(MiAaPQ)AAI3455728
Date Available in IDEALS:2015-09-28
Date Deposited:2010


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