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Title:Fatty Acid and Biotin Metabolism in Escherichia Coli
Author(s):Subrahmanyam, Satyanarayana
Doctoral Committee Chair(s):Cronan, John E., Jr
Department / Program:Microbiology
Discipline:Microbiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:Biotin which is essential for the synthesis of fatty acids in E. coli is thought to be derived from a modified fatty acid pathway. In experiments used to verify this hypothesis I discovered a new intermediate in biotin synthesis. This intermediate `X', was purified from the spent growth medium of strain sup151 (isolated as a bypass suppressor of a bioH mutation). Genetic data suggests that this intermediate is made by the action of the bioH and bioC gene products and its production is repressed by high levels of biotin in the growth medium via the BirA protein.
Issue Date:1998
Type:Text
Language:English
Description:176 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998.
URI:http://hdl.handle.net/2142/86739
Other Identifier(s):(MiAaPQ)AAI9912390
Date Available in IDEALS:2015-09-28
Date Deposited:1998


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