Files in this item

FilesDescriptionFormat

application/pdf

application/pdf9953146.pdf (4MB)Restricted to U of Illinois
(no description provided)PDF

Description

Title:A Novel Locus of Salmonella Typhimurium Involved in Survival in the Peyer's Patches
Author(s):Stanley, Theresa Luceil
Doctoral Committee Chair(s):Slauch, James M.
Department / Program:Microbiology
Discipline:Microbiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Molecular
Abstract:One of these Salmonella-specific genes, mil-VI , is regulated such that it is only expressed while the bacterium is in the small intestine. Virulence studies using mil-VI mutations further demonstrated that the mil-VI gene product is only required during the early stages of the infection process following oral inoculation. We have localized the function of mil-VI to survival and/or growth of Salmonella in Peyer's patches. Peyer's patches are regions of specialized lymphoid tissue involved in the uptake and processing of luminal antigens. Salmonella are capable of colonizing the Peyer's patch and can survive and multiply within the lymphoid tissue. We have renamed this locus gipA (g&barbelow;rowth i&barbelow;n P&barbelow;eyer's patches). Future analysis of this locus will lead to a better understanding of the process Salmonella uses to infect the small intestine of the host.
Issue Date:1999
Type:Text
Language:English
Description:133 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.
URI:http://hdl.handle.net/2142/86751
Other Identifier(s):(MiAaPQ)AAI9953146
Date Available in IDEALS:2015-09-28
Date Deposited:1999


This item appears in the following Collection(s)

Item Statistics