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Title:Directed Evolution of T Cell Receptor Antagonists
Author(s):Kieke, Michele Catherine
Doctoral Committee Chair(s):Kranz, David M.
Department / Program:Microbiology
Discipline:Microbiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:In Chapter 4, further engineering of TCR stability mutants to produce increased affinity binding for SAg is described. An optimized TCR fragment (containing nine mutations) was isolated after mutagenesis and selection, and was found to have approximately 1000-fold improved affinity for SAg. A soluble form of the mutant was shown to completely and specifically inhibit T cell activity in vitro.
Issue Date:2001
Type:Text
Language:English
Description:135 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.
URI:http://hdl.handle.net/2142/86768
Other Identifier(s):(MiAaPQ)AAI9996644
Date Available in IDEALS:2015-09-28
Date Deposited:2001


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