Files in this item

FilesDescriptionFormat

application/pdf

application/pdf3086192.pdf (12MB)Restricted to U of Illinois
(no description provided)PDF

Description

Title:Expression of Cytosolic and Mitochondrial Superoxide Dismutases: Their Role in the Chemoresistance of Malignant Melanoma
Author(s):Sulaimon, Shola Shakirat
Doctoral Committee Chair(s):Barbara E. Kitchell
Department / Program:Veterinary Clinical Medicine
Discipline:Veterinary Clinical Medicine
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Cell
Abstract:In summary, MM cells that are exposed to sublethal doses of ROS generating chemotherapeutic agents are able to modulate antioxidant defenses as an adaptive response. By upregulating Mn-SOD without commensurate increase in catalase activities, an imbalance in oxidant processing occurs. This imbalance in the antioxidant defense system results in accumulation of peroxides, which can act as secondary messengers to enhance cell survival pathways.
Issue Date:2003
Type:Text
Language:English
Description:269 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003.
URI:http://hdl.handle.net/2142/87124
Other Identifier(s):(MiAaPQ)AAI3086192
Date Available in IDEALS:2015-09-28
Date Deposited:2003


This item appears in the following Collection(s)

Item Statistics