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Title:Phenobarbital Regulation of CYP2B2, Cyp2b10, and Cyp2b9
Author(s):Rivera-Rivera, Ilia Damaris
Doctoral Committee Chair(s):Byron Kemper
Department / Program:Molecular and Integrative Physiology
Discipline:Molecular and Integrative Physiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Cell
Abstract:A new in vivo protocol, mouse tail vein injections, was developed to study PB induction of the mouse Cyp2b10 and Cyp2b9 PBRUs. In this model, the Cyp2b10 PBRU, which is 91% similar to the CYP2B2 PBRU, was induced by PB. A construct harboring the Cyp2b9 PBRU, which is 73% similar to the Cyp2b10 PBRU, was not PB responsive. Analysis of the PB responsiveness of Cyp2b10 PBRU mutants showed that Cyp2b10 and CYP2B2 may share the same mechanism of PB induction in which NR1 and NF-1 are the most important elements. The GRE-like and AF-1 elements also participate in the PB induction of Cyp2b10.
Issue Date:2001
Description:129 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.
Other Identifier(s):(MiAaPQ)AAI3017196
Date Available in IDEALS:2015-09-28
Date Deposited:2001

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