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Title:Estrogen Inducible Serpin, Proteinase Inhibitor 9, in Immunosurveillance and Apoptosis
Author(s):Jiang, Xinguo
Doctoral Committee Chair(s):Shapiro, David J.
Department / Program:Molecular and Integrative Physiology
Discipline:Molecular and Integrative Physiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Chemistry, Biochemistry
Abstract:The phytoestrogen genistein has attracted a great deal of recent interest. In MCF-7 cells, we find that 10 nM genistein induces PI-9 as effectively as saturating E2, and genistein treated MCF-7 cells are resistant to NK cell mediated cytotoxicity. In ERalphaHA cells, the dose response curves for induction of PI-9 by E2 and by genistein are nearly identical and inducing PI-9 with genistein blocks NK cell mediated killing. Analysis of MCF-7 tumors produced in a mouse xenograft model shows that genistein, soy-products including soy flour and NovasoyRTM induce PI-9 expression in vivo. Our data highlight the possibility that low concentrations of genistein might promote growth of pre-existing estrogen receptor-dependent breast cancer.
Issue Date:2007
Description:111 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
Other Identifier(s):(MiAaPQ)AAI3269928
Date Available in IDEALS:2015-09-28
Date Deposited:2007

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