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Title:Developmentally Related Increased Seizure Susceptibility to Pentylenetetrazole in Fragile X Knockout Mice
Author(s):Campos, Victor E.
Doctoral Committee Chair(s):Best, Philip M.
Department / Program:Molecular and Integrative Physiology
Discipline:Molecular and Integrative Physiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Molecular
Abstract:These experiments have demonstrated that fragile X knockout mice are more susceptible than control animals to the chemoconvulsant PTZ as adults, but not as juveniles. Furthermore, the temporal progression suggests that there is a developmental involvement in this seizure susceptibility. The mechanism of the seizure susceptibility and temporal progression are areas for further study. With a greater understanding of this general hyperexcitability, more effective treatments for fragile X patients can be devised.
Issue Date:2008
Type:Text
Language:English
Description:112 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
URI:http://hdl.handle.net/2142/87248
Other Identifier(s):(MiAaPQ)AAI3314737
Date Available in IDEALS:2015-09-28
Date Deposited:2008


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