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Title:Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes
Author(s):Chen, Chien-Chang
Doctoral Committee Chair(s):Best, Philip M.
Department / Program:Molecular and Integrative Physiology
Discipline:Molecular and Integrative Physiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Animal Physiology
Abstract:To test whether the LVA Ca$\sp{2+}$ channel contains $\beta$ subunit, I studied the ability of an AS ON $(\rm\beta\sb{all})$ targeting a common sequence of all four $\beta$ subunits to modulate the LVA Ca$\sp{2+}$ current in atrial myocytes. Our data showed that LVA Ca$\sp{2+}$ channels were inhibited by AS-$\rm\beta\sb{all}.$ These results support the idea that atrial T-type calcium channel is encoded by a member of the $\rm\alpha\sb{1E}$ calcium channel genes and is composed of at least the $\rm\alpha\sb{1E}$ and $\beta$ subunits.
Issue Date:1998
Description:117 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998.
Other Identifier(s):(MiAaPQ)AAI9904405
Date Available in IDEALS:2015-09-28
Date Deposited:1998

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