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Title:Integrated Entrainment of the Suprachiasmatic Clock by the Two Neurotransmitters of the Retinohypothalamic Tract, Glutamate and PACAP
Author(s):Dong, Chen
Doctoral Committee Chair(s):Gillette, Martha U.
Department / Program:Molecular and Integrative Physiology
Discipline:Molecular and Integrative Physiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Molecular
Abstract:The functional interaction between PACAP and Glu was then investigated. PACAP blocked the phase advance normally induced by Glu at late night, while anti-PACAP reagents augmented the Glu-induced phase advance in the SCN slice as well as the light-induced phase advance in vivo. In the early night, PACAP enhanced Glu-induced delay while PACAP antagonists inhibited it. Anti-PACAP reagents also decreased the basal level of cAMP suggesting a tonic release of PACAP. Thus, through the interplay of an amino acid neurotransmitter and a large peptide neurotransmitter, the RHT signals fine-tune the phase of the SCN clock to the surrounding light/dark cycle. This finding provides insight as to how monotonic sensory signal is transformed into a modulated, adaptive behavioral response.
Issue Date:1999
Description:128 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.
Other Identifier(s):(MiAaPQ)AAI9944816
Date Available in IDEALS:2015-09-28
Date Deposited:1999

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