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Title:Multiple Genetic Loci Control Susceptibility and Disease Characteristics in Murine Experimental Allergic Encephalomyelitis
Author(s):Butterfield, Russell James
Doctoral Committee Chair(s):Schook, Lawrence B.
Department / Program:Veterinary Pathobiology
Discipline:Veterinary Pathobiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Health Sciences, Immunology
Abstract:We identified 21 regions of the mouse genome that control EAE susceptibility, disease subtype, and clinical or histological disease parameters. Our results suggest that different clinical subtypes of EAE are immunogenetically distinct. In addition, the severity, duration, and day of onset are genetically controlled. Lesion characteristics and location of lesions are modulated by numerous genetic factors and can be influenced by sex. Underlying genetic differences may explain the heterogeneity in disease course and prognosis among MS patients. In light of our findings, MS genetic studies should be stratified more stringently with respect to sex, lesion characteristics, and disease subtype.
Issue Date:2001
Description:102 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.
Other Identifier(s):(MiAaPQ)AAI3023026
Date Available in IDEALS:2015-09-28
Date Deposited:2001

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