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Title:Molecular Responses to Desialylation in a Rat Model of Induced Glomerulopathy
Author(s):Ringenberg, Michael Alan
Doctoral Committee Chair(s):Vimr, Eric R.
Department / Program:Veterinary Pathobiology
Discipline:Veterinary Pathobiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Animal Physiology
Abstract:In this study, adaptation of a previously described in vivo model of neuraminidase-induced glomerular injury is described in the rat. Information derived from the initial pilot studies has been used to formulate the hypothesis that loss of glomerular sialic acid, concomitant with functional glomerular damage, results in a re-sialylation event associated with sequentially increased levels of glomerular linkage-specific sialyltransferase transcript levels and activity. The results of these experiments provide insight into specific molecular responses of podocytes to injury, in addition to demonstrating the versatility of this animal model for descriptive and mechanistic studies regarding podocyte sialobiology.
Issue Date:2002
Type:Text
Language:English
Description:100 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/87620
Other Identifier(s):(MiAaPQ)AAI3044208
Date Available in IDEALS:2015-09-28
Date Deposited:2002


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