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Title:Osmoregulation in Trypanosoma Cruzi: The Role of the Acidocalcisome
Author(s):Rohloff, Peter John
Doctoral Committee Chair(s):Roberto Docampo
Department / Program:Veterinary Pathobiology
Discipline:Veterinary Pathobiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Health Sciences, Pathology
Abstract:Electron microscopic observations revealed a contractile vacuole coupled to acidocalcisomes in all three life cycle stages of the parasite. An aquaporin homologue localized to the acidocalcisomes and contractile vacuole. In epimastigotes expressing a GFP-aquaporin fusion protein, acidocalcisomes trafficked toward the contractile vacuole during hyposmotic stress in a cAMP- and microtubule-dependent fashion. This phenomenon was functionally significant, since aquaporin and microtubule inhibitors reduced the rate of volume recovery. Isolated contractile vacuoles were enriched in alkaline phosphatase, aquaporin, and some acidocalcisomal markers.
Issue Date:2003
Type:Text
Language:English
Description:179 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003.
URI:http://hdl.handle.net/2142/87623
Other Identifier(s):(MiAaPQ)AAI3101957
Date Available in IDEALS:2015-09-28
Date Deposited:2003


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