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Title:Farnesyl Pyrophosphate/geranylgeranyl Pyrophosphate Synthase of Toxoplasma Gondii: Its Role in the Parasite Isoprenoid Pathway and as a Target for Bisphosphonates
Author(s):Ling, Yan
Doctoral Committee Chair(s):Silvia N.J.Moreno
Department / Program:Veterinary Pathobiology
Discipline:Veterinary Pathobiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Cell
Abstract:In summary, this work provides information to understand the isoprenoid pathway in T. gondii by isolation and characterization of an important enzyme in the pathway, TgFGGPS. Identification of TgFGGPS as the molecular target of bisphosphonates in this work provides a key tool for rational-based drug design. In addition, this work represents a new approach to chemotherapy of toxoplasmosis with a group of safe and easy to prepare compounds.
Issue Date:2005
Type:Text
Language:English
Description:103 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.
URI:http://hdl.handle.net/2142/87630
Other Identifier(s):(MiAaPQ)AAI3199069
Date Available in IDEALS:2015-09-28
Date Deposited:2005


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