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Title:Mass Spectrometric Interrogation of Thioester-Bound Intermediates on Nonribosomal Peptide and Polyketide Assembly Lines
Author(s):Hicks, Leslie Mae
Doctoral Committee Chair(s):Kelleher, Neil L.
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Chemistry, Biochemistry
Abstract:Innovative developments in MS continue to increase the complexity of biological systems amenable for study and provide exciting research opportunities at interdisciplinary boundaries. The doctoral studies presented here have furthered the understanding of the biosynthesis of key natural products produced by NRPSs and PKSs. Valuable information has been attained by intersecting interests in pharmacognosy with enzymology and by pushing the limits of current analytical technologies. Further, this research has solidified an intellectual framework to enhance the bioengineering of novel catalysts for creation of new biologically relevant compounds.
Issue Date:2005
Description:147 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.
Other Identifier(s):(MiAaPQ)AAI3202104
Date Available in IDEALS:2015-09-28
Date Deposited:2005

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