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Title:Development of Functional DNA -Based Sensors and Investigations Into Their Mechanism
Author(s):Nagraj, Nandini
Doctoral Committee Chair(s):Lu, Yi
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Chemistry, Inorganic
Abstract:The starting point towards the development of a successful functional nucleic acid-based sensor is its isolation and this is done through in vitro selection. In vitro selection to isolate DNAzymes for Hg2+ and Cd2+ and the use of negative selections to overcome Pb 2+ interference at various stages of selection has been described in Chapter 5. Chapter 6 describes the structure-switching strategy to isolate DNA aptamers specific for endotoxins. It is anticipated that the results obtained from the current study and future characterizations will lead to the development of functional DNA sensors for endotoxins.
Issue Date:2010
Description:208 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2010.
Other Identifier(s):(MiAaPQ)AAI3431021
Date Available in IDEALS:2015-09-28
Date Deposited:2010

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