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Title:Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein
Author(s):Nichols, Daniel B.
Doctoral Committee Chair(s):Joanna Shisler
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Virology
Abstract:Using a series of MC160 deletion mutant proteins, we found that two distinct regions of the MC160 protein independently inhibit TNF-mediated NF-kappaB activation. Specifically, we observed that the second DED of MC160 interacts with procaspase-8 as a means to inhibit NF-kappaB activation, while the C-terminus of MC160 interacts with the chaperone Hsp90. Because both procaspase-8 and Hsp90 associate with the IKK complex, we believe that the MC160 protein binds these proteins as a means to destabilize the IKK complex, resulting in reduced IKK activation, and ultimately, inhibition of NF-kappaB activation.
Issue Date:2008
Description:169 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
Other Identifier(s):(MiAaPQ)AAI3347488
Date Available in IDEALS:2015-10-14
Date Deposited:2008

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